2026.06.12
The 5th Keio University WPI-Bio2Q International Symposium
The 5th Keio University WPI-Bio2Q International Symposium “Wiring the Body: Brain–Organ–Microbiome Networks” Greetings Registration Invited Speakers Program Access Committees Links The 5th Keio University WPI-Bio2Q International Symposium Wiring the Body: Brain–Organ–Microbiome Networks ◆Date: December 9 Wednesday - 10 Thursday, 2026 ・Day1 (Dec 9) 9:00-19:00 Lectur...
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2026.05.20
Open Call: Postdoc and Postdoc Intern Positions at Quantum Computing core
The Quantum Computing Core of the WPI Bio2Q Research Center at Keio University is inviting applications for the position of Postdoctoral Fellowships and Postdoctoral Internships. We look forward to receiving applications from those who are creative, highly-motivated scientists willing to dynamically engage in Bio2Q-related research. ※Application Information for Postdoctoral fellowships ※A...
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2026.10.07
【10/14, 15 Seminar】 WPI-Bio2Q Open Seminar: Amelia Palermo, PhD＆Sonomi Yamaguchi...
Keio University Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q) will hold seminars as follows. These events are only for faculty, students, and staff of Keio University, and pre-registration is required. Session #1 Date and Time Wednesday, October 14, 2026, 15:00-16:00 Title Mining novel druggable vulnerabilities by systems biology of metabolism and artificial inferenc...
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2026.10.02
Research Internship Program 2027
Join Bio2Q! We welcome Bachelor’s and Master’s students from diverse backgrounds, who wish to pursue a Master’s or PhD program in a field related to Bio2Q. ELIGIBILITY PROGRAM PERIOD FINANCIAL SUPPORT VOICES OF PAST INTERNS PATHWAY TO GRADUATE SCHOOL DEADLINE APPLICATION PROCESS FAQ CONTACT ELIGIBILITY Graduate School of Medicine: Bachelor’s and Master’s student...
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2026.10.07
【Event】Participation in Keio University’s “Yotsuya Festival”
Keio University Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q) participated in the following event. Keio University Shinanomachi Campus “Yotsuya Festival” October 3 (Sat) 11:00 AM – 4:00 PM October 4 (Sun) 10:00 AM – 3:00 PM In addition to introducing Bio2Q’s research activities, we also hosted a Science Art Gallery on the day of the event. We welcomed 278 visitors and estab...
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【11/13 Seminar】WPI-Bio2Q Open Seminar: Richard I. Morimoto, PhD
Keio University Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q) will hold a seminar as follows. This is an event for faculty, students, and staff of Keio University. Date＆Time 10:30～11:30, November 13, 2026 Venue JKiC 1F, Seminar Room, Shinanomachi Campus, Keio University Title Systems Proteostasis in Aging: Cell-Non-Autonomous Stress Responses Across Tissues ...
【Publication】Identification and characterization of CXCL13 producers in bone tis...
Co-authored by researchers from Bio2Q and published in the journal International Immunology, this study clarifies how fasting alters the immune environment within bone marrow and promotes the migration of specific immune cells (naive B cells). The researchers identified a series of pathways in which metabolic changes accompanying fasting induce bone cells to secrete signaling molecules that attrac...
【Publication】Inhibition of Mincle signaling by chemically synthesized disacchari...
Co-authored by researchers at Bio2Q and published in Chemical Communications, this study discovered plant-derived compounds that suppress excessive inflammatory responses in the body. The researchers artificially synthesized components found in yams and investigated their effects on the immune mechanism. The results revealed that altering the structure of these compounds can inhibit the triggers o...
【Publication】Accurate, sensitive, and efficient chromatin accessibility quantifi...
Co-authored by researchers at Bio2Q and published in Nature Communications, this study developed a new analytical technology to accurately and efficiently examine how disease-related genetic variations function within the body. The researchers established a high-precision measurement method capable of capturing subtle changes, applying it to the data analysis of genes involved in immune diseases a...
【Publication】Mixed-class J-domain protein scaffolds promote expanded aggregate h...
Co-authored by researchers at Bio2Q and published in FEBS Letters, this study elucidates a new degradation mechanism by which human cells remove harmful protein aggregates. The researchers discovered that when multiple auxiliary proteins work together to recruit the main degradase, the degradation capacity and the range of waste types that can be processed are significantly increased. These findin...
【10/1 Seminar】WPI-Bio2Q Open Seminar: Djenet Bousbaine, PhD
Keio University Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q) will hold a seminar as follows. This is an event for faculty, students, and staff of Keio University. Date＆Time 17:00 -18:00, October 1, 2026 Venue 1F Lounge, Center for Integrated Medical Research, Shinanomachi Campus, Keio University Title Engineering Skin Bacteria for Needle-Free Topical Vaccinatio...
【Publication】Lysophosphatidic acid drives to mirror-image pain via corpus callos...
Co-authored by Bio2Q researchers and published in Communications Biology, this study clarifies how lysophosphatidic acid (LPA) propagates inflammation via the corpus callosum to induce mirror-image pain following a stroke. Through analyses using mouse models, the researchers identified that LPA triggers the transmission of inflammatory signals to the contralateral hemisphere via microglia. Consequ...
【Publication】Parallelizable search-space decomposition for large-scale combinato...
Co-authored by Bio2Q researchers (Scientific Reports), this study significantly accelerates large-scale optimization by splitting problems for parallel processing. Using a QUBO-based decomposition method, it cuts variables by up to 95% and reduces a 30-minute computation to just one minute. This achievement contributes to accelerating large-scale optimization across various fields, including logis...
Bio2Q to Participate and Exhibit at the 15th WPI Science Symposium
The 15th WPI Science Symposium will be held on Saturday, November 14, 2026, at the Osaka University Suita Campus Convention Center. This year’s theme is "World Premieres Born from Me! ~Science I Want to Share with Someone~." All 18 centers of the World Premier International Research Center Initiative (WPI) will gather for a wide range of programs. Highlights include a special lecture by Nobel L...
【Publication】Mitochondria-targeting ACSL6 variant drives mitochondrial fragmenta...
Co-authored by researchers from Bio2Q and published in Scientific Reports, this study reveals how a short ACSL6 enzyme variant selectively targets mitochondria to locally convert omega-3 DHA into DHA-CoA. By activating Drp1-dependent fission pathways, this localized lipid production triggers mitochondrial fragmentation. As a result, they were able to demonstrate a direct link between variant-speci...
【Publication】bifidoAnnotator: fine-grained annotation of bifidobacterial glycosi...
Co-authored by Bio2Q researchers and published in Microbial Genomics, this study presents "bifidoAnnotator," a tool designed for the highly accurate analysis of bifidobacterial enzymes involved in human milk glycan (HMG) metabolism. The researchers constructed a curated proprietary database of over 22,000 enzymes, achieving precise functional annotation an order of magnitude faster than convention...
【Publication】Visualizing Newly Synthesized Proteins and Their Degradation Dynami...
Co-authored by researchers from Bio2Q and published in the journal Bioconjugate Chemistry, this study developed a new technology to observe the real-time process of proteins in living cells from "birth to degradation." Using cell-friendly, long-wavelength fluorescent probes combined with click chemistry, the researchers selectively labeled newly synthesized proteins inside living cells. As a resul...
【9/14 Seminar】WPI-Bio2Q Open Seminar: Nicolas Manel, PhD
Keio University Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q) will hold a seminar as follows. This is an event for faculty, students, and staff of Keio University. Date＆Time 17:00 -18:00, September 14, 2026 Venue 2F Meeting room, Center for Integrated Medical Research, Shinanomachi Campus, Keio University Title "Intracellular DNA Sensors: From Antiviral Immunity...
【Publication】Fluorescent-labeled anti-inflammatory α-galactosylceramide derivati...
Co-authored by researchers at Bio2Q and published in Bioorganic & Medicinal Chemistry Letters, this study elucidates the mechanism of selective immune activation using fluorescently labeled anti-inflammatory glycolipids. The researchers developed a method to label anti-inflammatory glycolipids with fluorescence while maintaining their biological activity, allowing them to observe their intrace...
Open Call: Research Administrator (URA)
Bio2Q is seeking a Research Administrator (URA) (Project Instructor or Project Assistant Professor) to promote Bio2Q-related research through their own ideas and initiative. For further details, please refer to the link below. We look forward to receiving your application. Application Information → https://bio2q.keio.ac.jp/wp-content/uploads/3_URA.pdf
【Publication】Factorization machine with quadratic-optimization annealing for RNA...
Co-authored by Bio2Q researchers and published in the journal Scientific Reports, this study proposes an efficient RNA design method using a factorization machine with quadratic-optimization annealing (FMQA) to tackle the "RNA inverse folding problem"—identifying nucleotide sequences that adopt a specified target secondary structure. The researchers comprehensively analyzed nucleotide encoding met...
【Publication】Metagenomic sequencing as a diagnostic tool for urine culture negat...
Co-authored by Bio2Q researchers and published in the Journal of Infection, this study demonstrates that metagenomic sequencing serves as an effective diagnostic tool for febrile urinary tract infections (fUTIs) where conventional urine cultures fail to identify the causative pathogen due to prior antibiotic administration. By analyzing urine samples from patients with bloodstream-confirmed fUTIs,...
【Event Report】MEXT Children’s Kasumigaseki Tour Day
Keio University Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q) exhibited at the following event. MEXT Children’s Kasumigaseki Tour Day Ministry of Education, Culture, Sports, Science and Technology (MEXT) Wednesday, July 29, 10:00 a.m.–4:00 p.m.; Thursday, July 30, 10:00 a.m.–4:00 p.m. Ministry of Education, Culture, Sports, Science and Technology, 3-2-2 Kasumigaseki, Chiyoda...
【Publication】Quantum algorithm for metabolic network analysis
Authored by Bio2Q researchers and published in Machine Learning with Applications, this study demonstrates a novel quantum algorithm designed to accelerate large-scale metabolic network analysis. The researchers applied Quantum Interior Point Methods (QIPM) and Quantum Singular Value Transformation (QSVT) to Flux Balance Analysis (FBA), establishing an efficient method for solving complex metaboli...
WPI-Bio2Q Newsletter “Bio2Q Connect” Vol.2, Issue 17 Published
WPI-Bio2Q has published the latest issue of its newsletter, “Bio2Q Connect,” today on July 29, 2026. This issue covers the following updates and activities from across the center: Featured Topics: The 3rd Bio2Q "LEAD50" Lectureship Report: Ms. Yukako Uchinaga (President & CEO, GRI) lectured on "Diversity Management as a Business Strategy," emphasizing diversity as a key driver of i...
