慶應義塾大学 ヒト生物学-微生物叢- 量子計算研究センター

Keio University  Human Biology Microbiome Quantum Research Center (Bio2Q)

Integrating Biology, Microbiome and Quantum Computing for Healthy Longevity

Bio2Q Symbol



Research Internship Program 2024

Bio2Q is now offering a research internship opportunity as part of STaMP, a joint cross-disciplinary graduate English program for students i...


Keio University WPI-Bio2Q Publication

Retrotransposon renaissance in early embryos. Trends in Genetics (2023). DOI:10.1016/j.tig.2023.10.010


Keio University WPI-Bio2Q Publication

Hybrid Optimization Method Using Simulated-Annealing-Based Ising Machine and Quantum Annealer. J. Phys. Soc. Jpn. 92, 124002 (2023). DOI: 10...


Bio2Q 1st Anniversary

We are pleased to announce that Bio2Q celebrated its first anniversary on November 11th, 2023.Congratulations and heartfelt thank you to all...

Mission of Bio2Q

Human health is maintained by complex interactions between multiple organs. These interactions include the microbiome, which exists on every external surface of the body, and the resulting information is processed and utilized in a coordinated manner.

Our center will develop novel research techniques to understand the interactions between multiple organs and the microbiome and develop methods to apply quantum computing to human biology. Our mission is to forge a new interdisciplinary research area that will lead to groundbreaking progress in elucidating the regulatory mechanisms sustaining human health. In the long term, we will develop new prophylactic/therapeutic approaches to promote healthy longevity.

Identity of Bio2Q

World leaders in microbiome research, organoid technology, metabolic analysis, neural circuit analysis, and quantum computing

Integration of cutting-edge technologies of the three research core units, the Multidimensional data analysis core, the Homeodynamics mechanistic analysis core, and the Quantum computing core, to promote fusion research

Application of Artificial Intelligence (AI) and quantum computing to further the understanding of human biology

Comprehensive, longitudinal clinical samples related to cancer, diabetes, obesity, neuropsychiatric disorders, developmental disorders, immune disorders, aging, and centenarians

A joint cross-disciplinary graduate English program (STaMP) between the Graduate School of Medicine, Graduate School of Pharmaceutical Sciences, and Graduate School of Science and Technology.

Message from Director

Prof. Kenya Honda

As Japan’s first microbiome research center, Bio2Q aims to understand the interactions between humans and their microbiome at the molecular level. We combine quantum computing with bioanalytical methods to understand such complexity and hope to develop new therapies for diseases that are currently difficult to treat. We are committed to making our organization globally competitive to attract a diverse team of researchers.

Members & Collaboration

Our Team

Bio2Q brings together world-leading experts across multiple life science disciplines, bioinformatics and quantum computing functionally organized into Bio-1 (Multidimensional data analysis), Bio-2 (Homeodynamics mechanistic analysis) and Q (quantum computing) core units.


Bio2Q is part of the collaborative network of world-leading researchers. Thus, Bio2Q collaborates with researchers from Harvard University, MRC-LMB, Nanyang Technological University, Riken, and Central Institute for Experimental Animals.



Accumulate multiomics data from humans and model organisms and compile a multidimensional database.


Elucidate the structure and function of microbiome-derived metabolites.


Refine imaging metabolomics and structural biology to promote in situ functional analysis of metabolites in organs and cells.


Develop quantum computing-based algorithms and pipelines to analyze the interactions between multiple organs and microorganisms.


Model the interface between the environment and the human body by advancing organoid technology and animal models and elucidate the mechanisms underlying the conversion of external factors into internal signals.


Leverage connectomics and structural biology to understand the dynamic multiorgan interactions, including gut-brain communication.


  • Bio 1 Core
  • Bio 2 Core
  • Q Core
Multiorgan Interactions



A joint cross-disciplinary graduate
English program

Bio2Q plans to establish a joint cross-disciplinary graduate English program called STaMP (Science and Technology, and Medicine, Pharmacy) between the Graduate School of Medicine, the Graduate School of Pharmaceutical Sciences, and the Graduate School of Science and Technology. The Bio2Q STaMP program will be a “place of resonance” where faculty, researchers, and students from the three graduate schools can directly interact with one another. This will enable each graduate student to work with multiple mentors and receive guidance that transcends graduate school boundaries.

STaMP aims to achieve the following:

  1. Shared mentor program
  2. Research internship program
  3. Symposium & retreat led by graduate students
  4. Cross-listed graduate workshops
  5. High school outreach program

Open Positions

We are currently recruiting for
the following positions:


Keio University Human Biology Microbiome Quantum Research Center (Bio2Q)




    +81 3 6709 8106


    35 Shinanomachi, Shinjuku-ku,
    Tokyo 160-8582 Japan