RESEARCH
[Publication] Mitochondrial cardiolipin remodeling facilitates efficient myoblast differentiation
November 19, 2025
Credits: WPI-Bio2Q
Researchers from Bio2Q and Keio University found that mitochondrial lipid remodeling plays a key role in early muscle cell differentiation. They linked cardiolipin changes to mitochondrial activation, highlighting lipid metabolism as a regulator of muscle development and regeneration.
| Title | Mitochondrial cardiolipin remodeling facilitates efficient myoblast differentiation |
|---|---|
| Authors | Yohsuke Ohba [1],[2], Chinami A. Fujiwara [1], Makoto Arita [1],[2],[3],[4] |
| Short Description | Researchers at Bio2Q, Keio University, and collaborating institutions have uncovered a key role for mitochondrial membrane lipid remodeling in the early stages of myoblast differentiation. Through lipidomic analyses of differentiating muscle cells, researchers observed a sharp increase in linoleic acid (C18:2)-containing cardiolipin (CL) during the onset of differentiation. This remodeling correlates with increased expression of tafazzin, the mitochondrial enzyme responsible for cardiolipin maturation, and reflects a shift toward a more bioenergetically active mitochondrial state. Similar remodeling patterns were observed in differentiating primary skeletal muscle stem cells, indicating a conserved physiological mechanism. By linking cardiolipin remodeling to mitochondrial activation during differentiation, the study reframes lipid metabolism as an active regulatory layer in muscle development and regeneration. |
| DOI | https://doi.org/10.1016/j.jlr.2025.100909 |
| Journal | Journal of Lipid Research |
| Vol/Num/Page | 66(11) , 100909 |
| Publication Date | November 2025, 10009 |
Affiliations:
[1] Division of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences, Keio University, Tokyo, Japan
[2] Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa, Japan
[3] Cellular and Molecular Epigenetics Laboratory, Graduate School of Medical Life Science, Yokohama-City University, Yokohama, Kanagawa, Japan
[4] Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q), Keio University, Tokyo, Japan
SHARE
More Bio2Q News
【4/27 Seminar】WPI-Bio2Q Open Seminar: Soumya Raychaudhuri, MD, PhD
Keio University Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q) will hold a seminar as follows. This is an event for faculty, ...
Call for Principal Investigator Positions(Senior and Junior Levels) at Quantum C...
Bio2Q Center at Keio University is inviting applications for the position of Principal Investigators (Senior and Junior Levels), to be appoi...
Dr. Thomas CHATER Wins the "Prix du Public" at the 5th "Beauté Cachée de la Scie...
Dr. Thomas Chater, a researcher at WPI-Bio2Q, has been awarded the "Prix du Public" (Audience Award) in the 5th edition of the science photo...
【4/10 Seminar】WPI-Bio2Q Open Seminar: The 174th Brain Club & the 1st Structural ...
World Premier International Research Center Initiative (WPI) Bio2Q (Human Biology-Microbiome-Quantum Computing Research Center), in collabor...
【Seminar Report】WPI-Bio2Q Open Seminar: Damian R. Plichta, PhD
Keio University Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q) held a seminar as follows. 14:00 -15:00, April 3, 2026 V...
