RESEARCH
[Publication] Neuromodulation by the immune system: implications for brain-directed immunotherapy
July 28, 2025
Credits: WPI-Bio2Q
Co-authored by a Bio2Q researcher, this Review explores how the brain-immune axis acts as a key regulator of brain function and behavior through direct interactions with neural circuits. This work highlights how immunotherapies targeting neuroimmune pathways may offer therapeutic potential for psychiatric and neurological conditions.
| Title | Neuromodulation by the immune system: implications for brain-directed immunotherapy |
|---|---|
| Authors | Daniel H Cho [1],[2], Jun R Huh [3], [4],[5], Gloria B Choi [1],[2] |
| Short Description | This Review article, co-authored by a Bio2Q researcher, explores the growing recognition of the brain-immune axis as an important modulator of brain function and behavior, challenging the traditional view of the brain as immunologically isolated. This piece highlights how immune molecules, including cytokines and chemokines, influence neural activity, learning, memory, social behavior, and stress responses. The authors discuss the therapeutic potential of immunomodulatory approaches for neurological and psychiatric conditions, drawing on evidence from both animal models and clinical studies. This Review emphasizes recent findings that show immune signaling is a compelling target for brain-directed immunotherapy, and will provide a valuable resource that can be used to guide future research in neuroimmunology. |
| DOI | https://doi.org/10.1016/j.coi.2025.102568. |
| Journal | Current Opinion in Immunology |
| Vol/Num/Page | Volume 95, 102568 |
| Publication Date | 2025 June 6. |
Affiliations:
[1] Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA
[2] Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
[3] Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
[4] Human Biology Microbiome Quantum Research Center (Bio2Q), Keio University, Tokyo, Japan
[5] Lurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA
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