NEWS

NEWS TYPE
RELEASE YEAR

RESEARCH

[Publication] Neuromodulation by the immune system: implications for brain-directed immunotherapy

July 28, 2025

Co-authored by a Bio2Q researcher, this Review explores how the brain-immune axis acts as a key regulator of brain function and behavior through direct interactions with neural circuits. This work highlights how immunotherapies targeting neuroimmune pathways may offer therapeutic potential for psychiatric and neurological conditions.

タイトル Neuromodulation by the immune system: implications for brain-directed immunotherapy
著者 Daniel H Cho [1],[2], Jun R Huh [3], [4],[5], Gloria B Choi [1],[2]
簡単な説明 This Review article, co-authored by a Bio2Q researcher, explores the growing recognition of the brain-immune axis as an important modulator of brain function and behavior, challenging the traditional view of the brain as immunologically isolated. This piece highlights how immune molecules, including cytokines and chemokines, influence neural activity, learning, memory, social behavior, and stress responses. The authors discuss the therapeutic potential of immunomodulatory approaches for neurological and psychiatric conditions, drawing on evidence from both animal models and clinical studies. This Review emphasizes recent findings that show immune signaling is a compelling target for brain-directed immunotherapy, and will provide a valuable resource that can be used to guide future research in neuroimmunology.
DOI https://doi.org/10.1016/j.coi.2025.102568.
雑誌名 Current Opinion in Immunology
巻号ページ Volume 95, 102568
出版年月日 2025年6月6日

Affiliations:
[1] Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA
[2] Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
[3] Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
[4] Human Biology Microbiome Quantum Research Center (Bio2Q), Keio University, Tokyo, Japan
[5] Lurie Center for Autism, Massachusetts General Hospital, Lexington, MA, USA

More Bio2Q News

EVENT
2025.10.09

WPI-Bio2Q Social Event (2025.9.29)

WPI-Bio2Q held a social event at Keio University's Shinanomachi Campus. Date & Time: Monday, September 29, 2025, 12:00-13:00 Venue: ...

EVENT
2025.10.08

【Event】Keio Alumni Association Convention 2025

Keio University Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q) will give a presentation at the Keio Alumni Association Convent...

EVENT
2025.10.07

Visit to Bio2Q by Dr. Hitoshi Nakagama, President of the Japan Agency for Medica...

On September 22, 2025, Dr. Hitoshi Nakagama, President of the Japan Agency for Medical Research and Development (AMED), visited Bio2Q. Admi...

ANNOUNCEMENT
2025.10.02

Bio2Q Research Internship

The Keio University Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q) is offering a research internship as part of the STaMP prog...

ANNOUNCEMENT
2025.09.29

Newsletter “Bio2Q Connect” (Vol. 2, Issue 9)

We are delighted to share with you Vol. 2, Issue 9 of WPI-Bio2Q Newsletter “Bio2Q Connect”. Major topics of this issue include: Open S...