RESEARCH
[Publication] Microbiota-dependent modulation of intestinal anti-inflammatory CD4+ T cell responses
July 11, 2025
Credits: WPI-Bio2Q
This review, co-authored by a Bio2Q researcher, shows how gut microbes actively shape immunity and highlights new therapies like engineered probiotics and microbial editing for diseases like IBD.
| Title | Microbiota-dependent modulation of intestinal anti-inflammatory CD4+ T cell responses |
|---|---|
| Authors | Madeline Edwards [1] & Leonie Brockmann [2],[3] |
| Short Description | How Commensals Train the Gut Immune System This comprehensive review, co-authored by a Bio2Q researcher, highlights how microbial localization and metabolite production influence the host immune response. It explores promising therapeutic avenues, including engineered probiotics, targeted metabolite delivery, and microbial editing, that can be developed to treat inflammatory diseases such as IBD. Rather than being passive residents, gut microbes are active collaborators in maintaining immune homeostasis. This review serves as a valuable resource for the scientific community, offering insights into the microbiome’s role and the latest developments in the field. |
| DOI | https://doi.org/10.1038/s41586-025-08861-y |
| Journal | Springer Nature |
| Vol/Num/Page | Volume 47, article number 23 |
| Publication Date | 2025 April 1. |
Affiliations:01
[1] Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA
[2] Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA
[3] Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q), Keio University, Tokyo, 108-8345, Japan
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