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Keio University WPI-Bio2Q Publication

October 3, 2023

Gut microbial carbohydrate metabolism contributes to insulin resistance

Nature : volume 621, pages389–395 (2023)
DOI: 10.1038/s41586-023-06466-x

Tadashi Takeuchi1, Tetsuya Kubota1,2,3,4,5, Yumiko Nakanishi1,2, Hiroshi Tsugawa6,7,8,9, Wataru Suda10,  Andrew Tae-Jun Kwon11,  Junshi Yazaki12,  Kazutaka Ikeda7,13, Shino Nemoto1, Yoshiki Mochizuki12, Toshimori Kitami14, Katsuyuki Yugi15,16,17, Yoshiko Mizuno18,19, Nobutake Yamamichi20, Tsutomu Yamazaki21, Iseki Takamoto3,22, Naoto Kubota3, Takashi Kadowaki3,23, Erik Arner11, Piero Carninci24,25, Osamu Ohara12,13, Makoto Arita7,8,26,27, Masahira Hattori10, Shigeo Koyasu28 & Hiroshi Ohno1,2,8

1 Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
2 Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, Kawasaki, Japan.
3 Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
4 Division of Diabetes and Metabolism, The Institute for Medical Science Asahi Life Foundation, Tokyo, Japan.
5 Department of Clinical Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Tokyo, Japan.
6 Metabolome Informatics Research Team, RIKEN Center for Sustainable Resource Science (CSRS), Yokohama, Japan.
7 Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
8 Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.
9 Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Japan.
10 Laboratory for Microbiome Sciences, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
11 Laboratory for Applied Regulatory Genomics Network Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
12 Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
13 Department of Applied Genomics, Kazusa DNA Research Institute, Kisarazu, Japan.
14 Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
15 Laboratory for Integrated Cellular Systems, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
16 Institute for Advanced Biosciences, Keio University, Fujisawa, Japan. 
17 Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
18 Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
19 Development Bank of Japan, Tokyo, Japan.
20 Center for Epidemiology and Preventive Medicine, The University of Tokyo Hospital, Tokyo, Japan.
21 International University of Health and Welfare, Tokyo, Japan.
22 Department of Metabolism and Endocrinology, Tokyo Medical University Ibaraki Medical Center, Ami Town, Japan.
23 Toranomon Hospital, Tokyo, Japan.
24 Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
25 Fondazione Human Technopole, Milan, Italy.
26 Division of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences, Keio University, Tokyo, Japan.
27 Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q), Keio University, Tokyo, Japan.
28 Laboratory for Immune Cell Systems, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.

https://doi.org/10.1038/s41586-023-06466-x

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