Diet-mediated constitutive induction of novel IL-4(+) ILC2 cells maintains intestinal homeostasis in mice

Journal of Experimental Medicine. 2023
Volume220 Issue8, e20221773
DOI10.1084/jem.20221773

Cui, WL (Cui, Wanlin) [1] , [9] ; Nagano, Y (Nagano, Yuji) [2] , [3] ; Morita, S (Morita, Satoru) [1] ; Tanoue, T (Tanoue, Takeshi) [1] ; Yamane, H (Yamane, Hidehiro) [4] ; Ishikawa, K (Ishikawa, Keiko) [5] ; Sato, T (Sato, Toshiro) [5] ; Kubo, M (Kubo, Masato) [2] , [7] ; Hori, S (Hori, Shohei) [8] ; Taniguchi, T (Taniguchi, Tadatsugu) [3] , [6] ; Hatakeyama, M (Hatakeyama, Masanori) [3] , [10] ; Atarashi, K (Atarashi, Koji) [1] , [2] , [11] , [12] ; Honda, K (Honda, Kenya) [1] , [2] , [12]

1 Keio Univ, Sch Med, Dept Microbiol & Immunol, Tokyo, Japan
Affiliation
Keio University
Keio University School of Medicine Graduate School of Medicine
Keio University School of Medicine Graduate School of Medicine Department of Microbiology and Immunology
Keio University School of Medicine Graduate School of Medicine

2 RIKEN Ctr Integrat Med Sci IMS, Yokohama, Japan

3 Univ Tokyo, Grad Sch Med, Tokyo, Japan
Affiliation
University of Tokyo
The University of Tokyo Graduate School of Medicine Faculty of Medicine

4 NCI, NIH, Ctr Canc Res, Lab Cellular & Mol Biol, Bethesda, MD USA
Affiliation
National Institutes of Health (NIH) – USA
NIH National Cancer Institute (NCI)

5 Keio Univ, Sch Med, Dept Organoid Med, Sakaguchi Lab, Tokyo, Japan
Affiliation
Keio University
Keio University School of Medicine Graduate School of Medicine

6 Univ Tokyo, Inst Ind Sci, Tokyo, Japan
Affiliation
University of Tokyo
The University of Tokyo Institute of Industrial Science

7 Tokyo Univ Sci, Res Inst Biomed Sci, Div Mol Pathol, Noda, Japan
Affiliation
Tokyo University of Science

8 Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo, Japan
Affiliation
University of Tokyo
The University of Tokyo Graduate School of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences

9 China Med Univ, Dept Pediat, Hosp 1, Shenyang, Peoples R China

10 Microbial Chem Res Fdn, Inst Microbial Chem BIKAKEN, Tokyo, Japan

11 Hokkaido Univ, Inst Genet Med, Ctr Infect Associated Canc, Sapporo, Japan

12 Keio Univ, Human Biol Microbiome Quantum Res Ctr WPI Bio2Q, Tokyo, Japan

https://doi.org/10.1084/jem.20221773