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3-Indoxyl Sulfate and O-Acetylcarnitine Are Potential Novel Biomarkers for Early Diagnosis of Esophageal Cancer

Hamada K, Ozawa Y, Okamoto H, Fukuda S, Soga T, Abe T, Motohashi H, Murakami S, Kamei T. Cancer Sci.  2026 November 9; 10.1111/cas.70570. doi:10.1111/cas.70570

Secondary bile acids disrupt hematopoietic stem cell homeostasis

Tadokoro Y, Arakawa H, Kobayashi M, Ueno M, Soga T, Hirao A. Stem Cell Reports.  2026 November 5; 103141. doi:10.1016/j.stemcr.2026.103141

The metabolic dependency on GLUT3 mediates smoking-induced NSCLC progression

Cheng FJ, Shen YC, Chen BR, Hu SW, Thuong LHH, Wei YL, He YH, Yeh YL, Zhang TW, Hsieh IS, Ko TY, Wu YC, Lien JC, Li YC, Lee DY, Chen CH, Tu CY, Chen ML, Kinanti NP, Sugiura Y, Zhang B, Tajima M, Fagarasan S, Hung MC, Tang CH, Huang WC. Cancer Lett.  2026 November 5; 218945. doi:10.1016/j.canlet.2026.218945

Multi-target phosphodiesterase inhibition overcomes adipose catecholamine resistance and ameliorates systemic lipotoxicity

Fujiki T, Takami J, Ihara K, Kawajiri K, Ishida R, Nagaoka K, Mori Y, Waseda Y, Yoshida S, Mandai S, Mori T, Susa K, Sato S, Kajimura S, Kagechika H, Sasano T, Fujii Y, Sohara E, Uchida S, Arita M, Ando F. Metabolism.  2026 November 2; 156819. doi:10.1016/j.metabol.2026.156819

Safe lysosomal sequestration of ferrous iron is mediated via cholesterol shielding and drives senescence and ferroptosis resistance

Yanatori I, Hirayama T, Son R, Murakawa Y, Matsuoka Y, Sugiura Y, Niwa M, Katsuno T, Tsujimoto M, Yasui H, Sato A, Nakanishi M, Iwai K. EMBO J.  2026 November 2; PMID: 42972090. doi:10.1038/s44318-026-00939-1

Rotation of the N-terminal helix triggers Gα activation

Arai H, Ikuta T, Kise R, Tatsumi M, Koizumi Y, Yanagawa M, Sasaki D, Tawfeeq C, Oshima HS, Yau WI, Shihoya W, Sljoka A, Taninaka K, Nureki O, Sunahara RK, Mio K, Sasaki YC, Inoue A. Nat Chem Biol.  2026 October 30; PMID: 42963404. doi:10.1038/s41589-026-02359-y

The rise in prevalence of autoantibodies neutralizing type I interferons reaches a plateau in centenarians

Mørk N, Jensen JA, Bastard P, Larsen LA, Bundgaard B, Nygaard M, Clemmensen SB, Tao C, Catts VS, Puel A, Vogt G, Lozada-Martinez ID, Anaya JM, Arai Y, Perminder SS, Okada S, Casanova JL, Christensen K, Cobat A, Mogensen TH. J Hum Immun.  2026 October 27; 3(1):e20260143. doi:10.70962/jhi.20260143

Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages

Guan C, Ryu S, Dong M, Zhu Y, Maeda R, Youm YH, Mohanty S, Kim HH, Orliaguet L, Dlugos T, Smith SR, Ravussin E, Onyuru J, Hoffman HM, Siebel S, Wang A, Wang Y, Kluger Y, Shaw AC, Kanneganti TD, LeBrasseur N, Sugiura Y, Dixit VD. Cell.  2026 October 23; S0092-8674(26)01207-9. doi:10.1016/j.cell.2026.09.061

Microbiota-Taurine Pathway Links Dietary Fiber to Mucosal Healing

Odakura R, Seki N, Nomura K, Inoue Y, Yakabe K, Akiyama M, Yao T, Okano S, Suda W, Masuoka H, Zhang X, Orikasa M, Omori M, Koma M, Maruyama T, Yanagisawa N, Murakami T, Mori H, Toyoda A, Suzuki J, Izuta H, Srirat T, Haneda T, Miki T, Ito M, Ito T, Shibuya T, Katsumata R, Nakato G, Mizutani S, Yamada T, Sasaki N, Hase K, Fukuda S, Nagahara A, Ishikawa D, Kim YG. Gastroenterology.  2026 October 21; S0016-5085(26)07351-8. doi:10.1053/j.gastro.2026.09.028

Microbiome-dependent phytosterol sulfates production and tissue distribution in mice

Tomita K, Nakano T, Morozumi S, Okahashi N, Arita M.  iScience.  2026 October 16; 29(11):117883. doi:10.1016/j.isci.2026.117883

Fibroblast-Derived PLA2G12A Amplifies Mast Cell Activation Through Extracellular Phospholipid Remodeling

Taketomi Y, Miki Y, Higashi T, Nagasaki Y, Kano K, Arita M, Aoki J, Murakami M. Cells.  2026 October 12; 5(20):1848. doi:10.3390/cells15201848

Butyrate Modulates CXCR4 Expression and IL-5-Induced Inflammatory Responses in Human Eosinophils

Matsuyama E, Miyata J, Kawashima Y, Konno R, Hasegawa Y, Mizobe M, Fukasawa Y, Onozato R, Otsu Y, Sunata K, Sasaki H, Masaki K, Kabata H, Arita M, Fukunaga K. Allergy.  2026 October 8; PMID: 42850681. doi:10.1111/all.70540

Lysophospholipase PNPLA7 is a critical checkpoint of phosphatidylcholine catabolism and turnover for skeletal muscle homeostasis

Matsumoto S, Seo H, Taketomi Y, Higashi T, Nagasaki Y, Sato H, Kawaguchi M, Nishito Y, Park J, Mizuguchi K, Hosomi K, Kunisawa J, Saito K, Kato K, Soga T, Hirabayashi T, Ogawa S, Murakami M. Cell Rep.  2026 September 30; PMID: 42815479. doi:10.1016/j.celrep.2026.118003

Loss of Newborn Neuron Function Promotes Aβ Accumulation in an Alzheimer's Disease Mouse Model

Tamura R, Kawabata R, Lei C, Li H, Hayashi D, Seki M, Suzuki Y, Hisatsune T. Aging Dis.  2026 September 24; PMID: 42809425. doi:10.14336/AD.2026.0713

The Gibbs free energy landscape based on liver metabolome revealed thermodynamic robustness against fasting and obesity

Abekawa T, Ohno S, Hirayama A, Soga T, Kuroda S. iScience.  2026 September 24; 29(10):117618. doi:10.1016/j.isci.2026.117618