世界トップレベル研究拠点（WPI）慶應義塾大学ヒト生物学-微生物叢-量子計算研究センター(Bio2Q)は以下のとおり公開セミナーを開催しました。

日時：2026年10月1日（木）17:00-18:00

会場：慶應義塾大学 信濃町キャンパス 総合医科学研究棟 1階 ラウンジ

講演者：Djenet Bousbaine, PhD
Postdoctoral scholar
Department of Bioengineering
Stanford University, US

演題：Engineering Skin Bacteria for Needle-Free Topical Vaccination

要旨：
The ubiquitous skin colonist Staphylococcus epidermidis elicits a CD8+ T cell response pre-emptively, in the absence of infection, but the scope and purpose of this program remain unclear. Here, we show that this colonist also induces a potent, durable, and specific antibody response. Colonizing mice with S. epidermidis engineered to display tetanus toxin fragment C elicits neutralizing antibodies that protect against lethal challenge. A related strain expressing a SpyCatcher moiety can be conjugated to recombinant immunogens, and the resulting commensal elicits long-lasting, high antibody titers, including robust nasal IgA. An enzymatic approach to display immunogens on gram-positive bacteria extends this strategy to genetically intractable commensals: Cutibacterium acnes labeled with immunogens elicits strong T and B cell responses. Thus, immunity to common skin colonists involves a coordinated T and B cell response, which can be redirected against pathogens as a novel form of topical vaccination.。