Annexin A1 is a cell-intrinsic metalloregulator of zinc in human ILC2s

Cell Reports
Volume 42, Issue 6, 27 June 2023, 112610

DOI: 10.1016/j.celrep.2023.112610

Misato Irie 1, Hiroki Kabata 2, Kotaro Sasahara 1, Momoko Kurihara 1, Yoshitaka Shirasaki 3, Takashi Kamatani 4, Rie Baba 1, Masako Matsusaka 1, Satoshi Koga 5, Katsunori Masaki 1, Jun Miyata 1, Yasutomo Araki 6, Toru Kikawada 6, Yasuaki Kabe 7, Makoto Suematsu 8, Mai Yamagishi 9, Sotaro Uemura 10, Kazuyo Moro 11, Koichi Fukunaga 1

Affiliations
1) Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
2) Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan. Electronic address: kabata.h@keio.jp.
3) Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.
4) Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan; Laboratory for Medical Science Mathematics, Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0032, Japan; Department of AI Technology Development, M&D Data Science Center, Tokyo Medical and Dental University, Tokyo 101-0062, Japan; Division of Precision Cancer Medicine, Tokyo Medical and Dental University Hospital, Tokyo 113-8519, Japan.
5) Laboratory for Innate Immune Systems, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
6) Nose Clinic Tokyo, 1-3-1 Kyobashi Chuo-ku, Tokyo 104-0031, Japan.
7) Department of Biochemistry, Keio University School of Medicine, Tokyo 160-8582, Japan.
8) WPI Bio2Q Research Center, Keio University and Central Institute for Experimental Medicine, Kawasaki, Kanagawa 210-0821, Japan.
9) Live Cell Diagnosis, Ltd., Asaka, Saitama 351-0022, Japan.
10) Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan.
11)  Laboratory for Innate Immune Systems, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan; Laboratory for Innate Immune Systems, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan; Laboratory for Innate Immune Systems, Osaka University Immunology Frontier Research Center, Suita, Osaka 565-0871, Japan.

https://doi.org/10.1016/j.celrep.2023.112610